Product overview
These human spinal motor neurons (MNs) are derived from a genetically engineered induced Pluripotent Stem Cell (iPSC) line carrying a homozygous M337V mutation in the TARDBP gene, which encodes the TDP-43 protein. This mutation is strongly associated with familial and sporadic Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD).
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